Research in this thesis investigates a simple, rapid, reproducible and specific liquid chromatography-mass spectroscopy (LC-MS) method for the simultaneous detection, confirmation and quantitation of beclomethasone dipropionate (BDP) and its metabolites beclomethasone monopropio…
"562" Result
Sort By:
The objective of this study is to improve the catalytic performance of silica-supported Fischer-Tropsch cobalt based catalyst. Iron and nickel catalyst were also briefly studied. Initial work focused on synthesis of porous silica via oxidative thermal decomposition of polydimeth…
Fluorinated compounds make up a large proportion of the output from both the pharmaceutical and agrochemical industries. However, there are still a limited number of methodologies involving the synthesis of such molecules. Six-membered nitrogen containing heterocycles such as py…
The Mg/Ca temperature proxy was applied for the first time to seasonality records in calcitic brachiopod shells, using a laser ablation tracking technique on both Recent and fossil material. Seawater temperature calibrations were established using modern Terebratulina retusa fro…
The industrial Cu/ZnO/Al2O3 heterogeneous catalyst has been in commercialisation for more than 50 years, whilst ambiguity still remains regarding its synthesis procedure. This involves a multi-step process, whereby each of these steps contributes to the resulting microstructural…
This thesis describes the synthesis and characterization (1H, 13C NMR, CHN, and X-ray) of new NHC ligands incorporating a triazine core and their complexation with Ag(I), Pd(II) and Ru(II) metals. Imidazolium salts [2.4H]I – [2.7H]Br and [2.10H] - [2.15H]Br were obtained by reac…
The solvent-free selective epoxidation of dec-1-ene has been achieved under mild conditions and using atmospheric oxygen as the sole oxidant. Furthermore this has been conducted in the absence of radical initiators which is a first for such an oxidation to the best of our knowle…
In this thesis, studies of the kinetic and mechanism of racemisation of several drug-like molecule have been presented. Chapter 1 provides background information on the general mechanisms of racemisation of drugs in general, and hydantoin derivatives. In particular including rev…
This thesis describes the use of Brønsted acid catalysis to promote 6-exo-trig cyclisations in the synthesis of N-heterocyclic compounds. In Chapter one, a general overview of alkaloid structures is given, together with a number of general ways for their synthesis, with a partic…
A procedure for using Molecular Dynamics (MD) simulations to provide essential fl uid and interface properties for subsequent use in Computational Fluid Dynamics (CFD) calculations of nano-scale fluid fl ows is presented. The MD presimulations enable an equation of state, consti…
HIV continues to be a global healthcare challenge, with estimates suggesting there are currently 35.5 million infected people globally. To date, there have been an estimated 36 million HIV/AIDS related deaths worldwide. The story is changing however, with the advent of Highly Ac…
Adverse drug reactions (ADR) are a major concern for the pharmaceutical industry and health practitioners as they can cause morbidity and in severe cases mortality. ADRs are one of the major reasons why drugs fail during clinical trials so research directed at predicting ADRs to…
Chronic pain is a global medical-health problem. It is estimated that approximately 20% of the adult population suffer from some form of chronic pain. Along with the physical and emotional burden that living with chronic pain brings to the individual, there is also a huge socio-…
The stereoselective construction of fused 5,7-bicycles has attracted considerable attention due to the ubiquity of this motif in complex biologically active sesquiterpene lactones (dehydrocostus lactone, helenalin). Transition metal-catalysed carbocyclisation reactions represent…
Malaria is one of the most prevalent and deadliest parasitic diseases affecting various systems of the body and leading to death. Resistance against antimalarial treatment is a major threat in controlling and eliminating malaria. New drugs are urgently needed especially when art…
The activation of carbon-hydrogen (C–H) and carbon-carbon (C–C) bonds by transition metal catalysts is an attractive strategy to streamline organic synthesis. Herein this manuscript, the two main areas of research are described. Firstly, it was found that a nickel catalyst can p…
Iron oxide magnetic nanocomposites can be used for a variety of biomedical applications, including magnetic resonance imaging (MRI) and as site specific drug delivery systems. By functionalising the surface of the nanocomposite, other functions like cell labelling and targeting …
Background: Neuroinflammation in the central nervous system involves the rapid reaction of the CNS through activation of resident immune cells (especially microglia cells) to infection, trauma and stroke, among other stimuli. It is a tightly regulated process but in chronic case…
This thesis is divided into four chapters in which one-pot processes have been developed and utilised for the synthesis of biologically active compounds. The work in the first chapter outlines the 13-step total synthesis of D -ribo- and L - arabino-phytosphingosine from D -ribos…
In this thesis, the structure and reactivity of Pd, Au and Au-Pd structures on TiO2(110) single crystals has been investigated with surface science techniques, including X-ray photoelectron spectroscopy (XPS), low energy ion scattering (LEIS), Auger electron spectroscopy (AES) a…