This thesis describes the use of organoborate rearrangement reactions to generate quaternary carbon centres, with the ultimate goal of exploring new procedures for the asymmetric synthesis of chiral quaternary carbon centres. Chapter One: this chapter contains a historical revie…
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The oxidative dehydrogenation (ODH) of n-octane to produce octene at atmospheric pressure has been studied using an industrially supplied iron molybdate catalyst from Johnson Matthey (JM). In situ X-ray diffraction studies revealed at temperatures ≥450 °C the catalyst undergoes …
Three areas of investigation regarding a novel class of anti-cancer therapeutics, triple-helicate dinuclear compounds known as ‘cylinders’, have been addressed. An improved protocol for the synthesis of a ruthenium cylinder has been developed, utilising microwave synthesis rathe…
Phyllaemblic acid is a spirocyclic acetal-containing natural product isolated from Phyllanthus emblica. A total synthesis of phyllaemblic acid has yet to be reported. The spirocyclic acetal portion of phyllaemblic acid is structurally similar to that found in the natural product…
This thesis concerns molecules with potential uses for information storage on the atomic scale. Density functional theory (DFT) calculations are used to study the molecules in depth, to further understand their properties and to ascertain whether they are suited to such applicat…
Microporous materials play an important role in a variety of industrial and domestic applications. While a diverse range of microporous materials have been identified, this thesis focuses on porous organic cages (POCs) because they have received much attention as synthetically t…
The formation of multi-functional thiol materials for “click” reactions in synthetic chemistry has been significantly under-represented due to added practices that are typically required when working with sulfur-containing compounds. An efficient and facile approach to approach …
There is accumulating evidence that reactive nitrogen species derived from nitric oxide metabolism are involved in cancer as they are able to damage DNA largely through oxidation or nitration of the guanine base. The 8-nitroguanine lesion is increasingly associated with cancers …
The development of the plastic electronics industry has drawn great interest and inspired technology innovations in a broad area. This has stimulated the rapid development of flexible circuitry manufacturing technologies, including advances in conductive inks, printing technolog…
This study aimed to prepare, characterise and test the performance of heterogeneous catalysts in the conversion of biomass-derived molecules including deoxygenation of propionic acid in the gas phase and the Prins condensation of β-pinene with paraformaldehyde in the liquid phas…
The selective hydrogenation and dehydrogenation of organic molecules is a fundamentally challenging and an attractive transformation for both, industry and academia. However, catalysts capable of undergoing both transformations under environmentally benign conditions are rare. I…
This thesis presents new experimental techniques and utilizes these strategies in the analysis of solid organic inclusion compounds. This thesis also reports the production of a new series of co-crystals and examines their crystal structures. Chapter 1 acts as an introduction to…
The aim of this project was to prepare novel ferrocene-based Hydrogen-bonding receptors and to study them in the electrochemical sensing of neutral compounds and in organocatalysed transformations. The synthesis and characterisation of 2-ferrocenyl oxazoles via gold chemistry to…
Nanoemulsions have been receiving a lot of interest due to their advantages: creaminess, better stability and more efficient delivery of neutraceuticals to the body. This work has developed the understanding of how to produce nanoemulsions efficiently using two high pressure dev…
Use of zeolite based catalysts for important petrochemical reactions was investigated. Specific reactions studied included dialkylation of naphthalene over HY zeolite, dehydration of methanol over ZSM-5 zeolite and hydrogenation of naphthalene over Ni/HY and Co/ZSM-5 zeolite. Fo…
In this thesis the development of regiocontrolled gold-catalysed reactions for the synthesis of complex heterocycles are described. A new methodology for the formation of all-carbon fully substituted oxazoles was designed and developed, through a novel gold-catalysed intermolecu…
Although mounting evidence suggests that Tamoxifen exerts cardioprotective effects against atherosclerosis, the findings that associate Tamoxifen and atherosclerosis at a molecular level are inconsistent and unclear. Tamoxifen is a potent autophagy inducer and we believe that th…
This thesis describes a body of original research focused on the development of a viable alternative to the indium-tin oxide (ITO) glass window electrode used in organic photovoltaic (OPV) devices, based on the use of ultra-thin Cu films. The first results chapter describes a lo…
The research presented in this thesis uses laboratory and synchrotron based structural techniques in combination with electrochemistry to test the durability of selected conservation methods. A new piece of portable spectroelectrochemical equipment (the peCell) is also described…