Thesiss

Avian influenza H5N1 is one kind of important bird flu. Unfortunately, this virus has swiftly evolved and become highly pathogenic to humans and poultry, resulting in 100% of death in infected poultry and over 60% of mortality among infected human population. Moreover, the virus…

Viruses are ubiquitous, obligate parasites that infect all forms of life. Despite their ubiquity and importance however they are mainly studied only in the contexts where they cause human disease. Most human viruses come from spillover events from other animals, therefore from a…

The evolution of antigenically variable viruses cannot be understood without studying the interaction between viruses and the host immune system. Viral evolution is driven by their fast acquisition of genetic variation as well as by the strong selection imposed by the host immun…