Foot and mouth disease (FMD) is endemic in many parts of the world (Anjum et al., 2006; Farooq et al., 2018, 2017a, 2017b, 2017c, 2016; Gleeson, 2002; Jamal et al., 2010; Navid et al., 2018; Rweyemamu et al., 2008; Yano et al., 2018), and it is associated with substantial econom…
Turkey Coronavirus (TCV) is the causative agent of an acute, highly infectious enteritis of turkey poults. The S1 subunit of the spike glycoprotein of TCV is the major inducer of virus neutralizing antibodies. The long range goal of this work is to prevent TCV infection using va…
Following aerosol exposure to virulent Escherichia coli, lung and tracheal samples were collected from Bordetella avium-infected (BA+) and B. avium-free (BA-) turkeys for bacterial quantitation and histopathologic examination. Pulmonary clearance of E. coli was not significantly…
Necropsies of several wild California condors indicated that they died from lead poisoning due to ingestion of lead from bullet fragments in carcasses of abandoned game animals. The purpose of this study was to evaluate the toxicity of alternative, non-lead based ballistic mater…
The overall objective of this dissertation was to evaluate the effects of dietary fiber and short-chain fatty acids on enterocyte differentiation, maturation, and susceptibility to coronavirus infection in turkeys. Initial work involved the development of an indirect immunoperox…
Experiments were conducted to determine the effect of astrovirus infection in hatchling turkeys. Additionally, the lectin-binding affinities of the small intestinal glycocalyx were investigated by direct biotin-strep-avidin technique in poults. Two to 5 day old poults were inocu…
The respiratory and pericardial lesions in turkeys infected with avian and mammalian strains of Chlamydia psittaci were quantitated to determine if chlamydial strains from different restriction endonuclease groups cause distinct disease syndromes. Immunohistochemistry and light …
The Pathogenicity of TAstV1987 and TAstV2001 isolates was investigated. Both isolates caused gastroenteritis and growth depression in specific pathogen free (SPF) turkey embryos and poults. TAstV1987 infection resulted in microscopic lesions of infected bursas of embryos and pou…
During the first stage of this study, a complete statistical analysis was performed on condemnation records from 1991-1997 at the four main processing plants in Ontario. Results of this part of the investigation indicated that airsacculitis was responsible for 14-36.5 percent of…
The imiquimod S-28828 induced high serum levels of type I IFN in turkeys after oral administration. Spleen, bone marrow and peripheral blood leukocytes produced IFN following in vitro stimulation with S-28828. High dose treatment of turkeys with S-28828 enhanced the mortality ra…
Serogroup A Pasteurella multocida is the major cause of fowl cholera in poultry. Resistance of P. multocida to phagocytosis in non-immunized birds is associated with the presence of a hyaluronic acid capsule. The studies presented in this dissertation were designed to (1) invest…
Archived formalin-fixed intestinal tissues, and frozen intestinal contents collected from 12 PEMS flocks in 1998 were used to determine the prevalence of EPEC in PEMS-affected turkey flocks. EPEC isolates were assessed for pathogenicity and ability to reproduce AE lesions in you…
The immunopharmacologic and immunopathologic mechanisms through which hemorrhagic enteritis virus (HEV) induces intestinal lesion formation associated with clinical infection is unknown. These studies were designed to (1) determine differences in age susceptibility to HEV infect…
Enteric disorders are becoming of increasing concern to the poultry industry. The causative agents of enteric diseases in turkeys include bacteria, viruses, parasites and antinutritional factors present naturally in feedstuffs. There were two general objectives of research repor…
The interaction of several pathogens with eimerian species of parasites was investigated in chickens and turkeys. No synergistic effect on mortality, weight gain or oocyst production during mixed infections of Trichomonas gallinarum and Eimeria adenoids in turkeys. There did how…
An in vitro biological assay system was utilized to evaluate the effects of cyclopiazonic acid (CPA) mycotoxin on turkey cardiac papillary muscle performance. Acute exposure to 6 ug CPA/ml of bathing solution significantly decreased five performance criteria of in vitro papillar…
Hemorrhagic Enteritis (HE) vaccine is perhaps the most commonly used vaccine in the turkey industry. Although it provides protection against clinical disease, the vaccine is still thought to produce transient immunosuppression. In the field, HE still remains a significant concer…
Infectious laryngotracheitis (ILT) is a respiratory disease of chickens caused by an alphaherpesvirus. Disease results in production losses due to condemnations, mortality and decreased egg production. ILT has been controlled using modified-live vaccines. Problems with vaccinati…