During each heart beat, the cerebrospinal fluid (CSF) flows back and forth between the cranium and spinal canal. This pulsatile flow is driven by the pulsatile blood flow to the cranial vault and is modulated by the biomechanical properties of the craniospinal system (e.g., intr…
This thesis consisted of experiments designed to explore the construct of attention and investigate the disruptive effects of psychotomimetics, with a specific focus on NMDA antagonists. Phencyclidine (PCP) was administered through a variety of treatment regimens in order to to …
Nanoparticles have potential biomedical applications because of their special physical properties. Multi-scale nanoparticles contrast agents are those particles that provide contrast in different scale imaging modalities. Such particles are of great interest for monitoring anti-…
Introduction and aim: Increases in the bioavailability of nitric oxide have been shown to reduce the oxygen (O2) cost of exercise, improve exercise performance, alter gastric blood flow and mediate glucose uptake in healthy individuals. Aim: Does dietary nitrate reduce the O2 co…
The move towards higher static magnetic field strengths in MRI has allowed improved imaging quality from increased signal to noise ratio. However challenges have arisen from increased inhomogeneity in the radio frequency (RF) fields required to create MR signals and greater RF e…
Iron platinum (FePt) has attracted growing interest because of its high Curie temperature, magneto-crystalline anisotropy and chemical stability. Nanoparticles (NPs) made of this alloy are promising candidates for a wide range of biomedical applications including magnetic separa…
Cocaine use is associated with high-risk sexual practices that accelerate the spread of human immunodeficiency virus (HIV) infection. Substantial literature has demonstrated that active substance use leads to impairment on assessments of executive function. Inhibitory control--t…