The experiments presented in this thesis describe the roles of the post-junctional α1, α2-adrenoceptors (AR) and P2X purinoceptors in response to sympathetic nerve stimulation in mouse mesenteric and tail arteries. Such roles were determined by combining wire myography technique…
"377" Result
Sort By:
Rheumatoid Arthritis (RA) is a chronic systemic inflammatory disease, which targets the synovial membrane and joints of patients, resulting in irreversible bone damage, and disability. The development of new treatments for RA is limited by our incomplete understanding of disease…
This PhD examines the role of individual and environmental characteristics in the intent to aggress, resulting in the development of a model to understand the intent to aggress in forensic settings. Study one focused on individual characteristics of aggressors in a prison sample…
Children and young people’s physical activity levels are of continuing concern as the health implications for both childhood, and later on in adulthood, may be determined by their experiences of physical activity whilst growing up. Although many attempts have been made to increa…
Body fluid identification (BFID) forms a crucial aspect within forensic investigations. BFID is particularly important where the origin of a DNA profile is also needed e.g. sexual assaults. The aim of this work was to develop a RNA-based BFID for use in forensic casework. The te…
This thesis illustrates the behaviour of cellulose ethers during powder processing, compaction and drug release, as these are frequently employed in the fabrication of compressed hydrophilic matrices. The handling operations can give rise to the electrification of powder particl…
Microplastic pollution has been identified as an ever increasing proportion of marine litter. Despite an increase in microplastic awareness over the last decade, it represents an as yet unquantified threat to the marine environment. The relatively few studies that monitor its di…
Most of the social cognitive and affective neuroscience in the past 3 decades has focussed on the face. By contrast, the understanding of processing social cues from the body and voice have been somewhat neglected in the literature. One could argue that, from an evolutionary poi…
Numerous testing regimes have been used in vitro to assess the fatigue behaviour of acrylic bone cements. While some attempts have been made to introduce an optimal protocol that measures the fatigue life of bone cement under similar stress conditions to those exist in vivo, the…
The present thesis is an enquiry into the nature and consistency of the idea of music as a metaphor throughout the works of the English philosopher and physician Robert Fludd (1573/4-1637). Fludd was very fond of a view of the world in which man is made of the same elements and …
With a globally ageing population diseases associated with this natural process are becoming major issues worldwide. Research into the process of ageing and its concomitant issues is rapidly expanding; the need for new tools and models to investigate this rapidly expanding arena…
Photosynthetic organisms harvest sunlight through antenna light-harvesting complexes. Light absorbed by chromophores is transferred down an energy gradient to a reaction centre (RC) where photoinduced electron transfer occurs. A charge-separated state is generated that preserves…
There is an increasing understanding of the influence seabirds have on island food webs globally, which often arises from the trans-boundary input of nutrients. Seabird-derived nutrients, primarily in the form of guano, can have significant effects on island communities by incre…
In this thesis I aimed to provide base-line data to inform conservation of neotropical otters (Lontra longicaudis ) at both the range-wide and local (Mexico) scale. In Chapter 2, I compared three commonly used preservation methods for faecal DNA in order to identify the best met…
Osteoarthritis (OA) is the most prevalent form of degenerative joint diseases and affects about 13% of the world’s population with patients over 65 years of age reflecting the largest group of patients (Matthews and Hunter 2011). OA is characterized by a progressive degeneration…
The C-type lectin-like receptor, CLEC-2, is constitutively expressed on platelets, with reported expression on a number of leukocyte subsets in adult mice. Constitutive or platelet-specific deletion of CLEC-2 in mice induces cerebral haemorrhaging by midgestation. In this thesis…
The progressive improvement in the operating performance of existing nuclear reactors has brightened the outlook for nuclear power around the globe. In order to use less carbon based power, the use of nuclear reactors provides an attractive solution. However, questions are raise…
Asbestinins are the most complex of the ether bridged 2,11-cyclised cembranoids, isolated from the gorgonian octocoral species Briareum asbestinum. They have a complex rigid tetracyclic framework with nine or more contiguous stereocentres and a highly substituted tetrahydrofuran…
Plastic pollution is a problem of global scale and will increase as synthetic polymers continue to be produced, used, and discarded. Microplastic (MPs, < 5 mm in size) pollution is of increasing concern, because this is estimated to account for more than 92% of global plastic co…