In Saccharomyces cerevisiae, Gpx3 is a H2O2 sensor that resides in the cytosol, the mitochondrial intermembrane space (IMS) and the peroxisomal matrix. Upstream translation from a non-AUG codon after exposure to H2O2 results in production of an N- terminally extended form, N18Gp…
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Mycobacterium abscessus is a multidrug resistant pathogen commonly isolated from patients with cystic fibrosis. Currently, there is no rapid diagnostic tool to detect the presence of M. abscessus. Rapid diagnosis followed by appropriate, prompt treatment remains the best curativ…
Enhanced geothermal system (EGS) reservoirs are artificial deep reservoirs designed to exploit geothermal power accumulated within hot dry rocks in order to generate electricity. EGS reservoirs have large potential to be exploited as a renewable source of energy. However, curren…
As the average life expectancy of populations across the world increases, there is a growing challenge to maintain the health of older adults into older age. Older adults are at greater risk of endothelial dysfunction, reduction in functional fitness and mental ill-health issues…
The adoption of social media and smart devices by millions of users worldwide over the last decade has resulted in an unprecedented opportunity for NLP and social sciences. Users publish their thoughts and opinions on everyday issues through social media platforms, while they re…
This thesis explores the ideological and the practical relationship between Marketisation and Education for Sustainable Development (ESD) in English higher education (HE) – focusing on the political-economic ideology of Neoliberalism and associated public sector management philo…
In the context of research highlighting the mixed performance of coastal climate change adaptation elsewhere, this thesis developed a modified Analysis-Awareness-Action (AAA) framework to evaluate local climate change adaptation in four coastal townships along the vulnerable sou…
The present dissertation discusses the relationship between cultural constructions of climate and practical attempts at regulating the latter’s perceived influence on human beings in the ‘long’ seventeenth century—a time of crucial historical and intellectual changes. Drawing up…
The Lost Foam Casting process has been firmly established for Aluminium and ferrous alloys. This process offers many advantages over conventional casting processes but its full potential has yet to be reached due to the many defects introduced to the casting associated with deco…
The main objective of this research was to understand phenomena occurring during food digestion and nutrients absorption in the small intestine from an engineering perspective. Intestinal flow and mixing processes were simulated using a dynamic in vitro Small Intestine Model (SI…
Background: Patient recruitment to trials is problematic; many fail to achieve targets, leaving them underpowered and unable to address their hypothesis. Few solutions have been identified in existing literature. This thesis aimed to: identify factors associated with recruitment…
The Brown Plant Hopper (BPH) is a serious pest of rice in Asia. Development of novel control strategies can be facilitated by a comparison of BPH feeding behaviour on varieties exhibiting natural genetic variation, and then an elucidation of the underlying mechanisms of resistan…
Food drying techniques such as air and freeze drying are not ideal: high temperatures used during air drying result in degradation of nutrients and sensorial properties, while freeze drying is expensive and therefore only applicable to high value foods. As an alternative to such…
Assessment of eutrophication of coastal waters has traditionally relied on bulk indicators of ecosystem state (e.g. nutrients and phytoplankton biomass as chlorophyll) and changes in phytoplankton oristic composition such as the occurrence of nuisance and harmful species. Inform…
Wind is an important source of renewable energy and is widely available, despite the changing condition. In recent years a growing number of manufacturers have produced small wind turbines suitable for utilisation by individual householders or small businesses. These systems are…
Matrix assisted laser desorption/ionisation mass spectrometry (MALDI-MS) is a relatively new technique for imaging lipids directly in tissue, with useful applications in disease state profiling, bacterial typing and forensics. This thesis describes optimisation and evaluation of…
Surface modification of polymers has long been known in polymer chemistry but has not yet been widely applied to biomaterials. A newly developed active screen plasma technology has a potential to treat such non-conductive materials as polymers to improve their surface properties…
Immunity to Salmonella infection requires an integrated immune response, encompassing Th1 cell-mediated and humoral immunity at discrete stages of infection. Primary infection of mice with attenuated Salmonella Typhimurium (STm) drives an atypical B cell response, characterised …
Recent years have seen a huge proliferation in the use of content in distributed applications. This observation has been exploited by researchers to construct a new paradigm called content-centric networking. Within this paradigm, applications interact with the network using a s…