Communication between the immune system and the central nervous system (CNS) is becoming increasingly topical as evidence suggests the two systems are intricately linked. Although the brain is considered an ‘immune-specialised’ tissue, it is not free from the influences of the p…
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Drosophila melanogaster has been an important model organism for over a century, cumulating in a vast array of mutant and transgenic stocks, the publication of the genome, its subsequent annotation and more recently the production of the online gene expression database, FlyAtlas…
Conventional communication networks route data packets in a store-and-forward mode. A router buffers received packets and forwards them intact towards their intended destination. Network Coding (NC), however, generalises this method by allowing the router to perform algebraic op…
Disorders of cartilage and tendon account for a high incidence of disability and are highly prevalent co-morbidities within the ageing population; therefore, musculoskeletal disorders represent a major public health policy issue. Despite considerable efforts to characterise bioc…
Plasmodium falciparum parasites have evolved numerous ingenious methods to subvert immune recognition, in order to survive within the human host. One such immune evasion mechanism features the expression of ligands which bind to the Fcportion of human IgM. The binding of IgM to …
Background: Salmonella bacteraemia is an important public health problem in children from sub Saharan Africa (SSA). Understanding what constitutes natural acquired immunity to Salmonella is crucial for the development of Salmonella vaccine. It was hypothesized that natural Salmo…
Nonnegative matrix factorization (NMF) has becoming an increasingly popular data processing tool these years, widely used by various communities including computer vision, text mining and bioinformatics. It is able to approximate each data sample in a data collection by a linear…
There is an overwhelming experimental and theoretical evidence indicating SF6 arc burning in a supersonic nozzle (known as the switching arc) is turbulent and in local thermodynamic equilibrium (LTE). Such an arcing arrangement is commonly used as the interrupter in gas blast ci…
Neutrophils are the major cellular constituent of blood leukocytes and play a central role in the inflammatory response, expressing an array of destructive molecules and antimicrobial processes that characterise the cells as front-line defenders of the innate immune system, thus…
Extracellular signal-regulated kinase 5 (ERK5) is the newest member of the mitogen- activated protein kinase (MAPK) family following the discovery of ERK1/2, JNK and p38 MAPK. ERK5 consists of an N-terminal kinase domain, similar to the other MAPK members, and a large C-terminal…
Toxoplasma gondii and Neospora caninum are intracellular protozoan parasites from the phylum Apicomplexa. Both parasites share many morphological and genetic features, but have diverse host preferences. While T. gondii can infect any warm-blooded animal including humans, N. cani…
Molecular mechanisms governing the plasticity of cellular boundaries in confluent epithelial monolayers are poorly characterised. In this thesis, we report a drastic reorganisation of cellular boundaries, provoked by the prolonged withdrawal of EGF from non-malignant mammary epi…
This thesis deals with the modeling and control of permanent magnet synchronous generator based wind turbines (PMSG-WTs). The PMSG-WTs are widely used in wind energy conversion systems(WECSs), due to their merits such as high reliability, high efficiency, low noise, high torque …
Due to the global energy crisis and environmental concerns, the development of sustainable energy is considered by more and more countries. In order to make this target, energy demand management is significantly necessary in which forecasting the energy demand is the starting po…
Background: Neuroinflammation in the central nervous system involves the rapid reaction of the CNS through activation of resident immune cells (especially microglia cells) to infection, trauma and stroke, among other stimuli. It is a tightly regulated process but in chronic case…
Recent research has indicated that variability of antecedent flows is a fundamental control on the entrainment and transport of sediment in river systems. Specifically, the low flows between successive floods appear to have a far greater influence on the stability of a river bed…
In this thesis we consider efficient algorithms for matching problems involving preferences, i.e., problems where agents may be required to list other agents that they find acceptable in order of preference. In particular we mainly study the Stable Marriage problem (SM), the Hos…
Honey possesses therapeutic properties which are the result of a range of factors including high sugar content, low pH, hydrogen peroxide and bee-derived peptides. Honey also contains antimicrobial phytochemicals which represent a rich source of leads for the development of drug…
Focal Adhesion Kinase (FAK) is an intracellular kinase known to mediate integrin signalling following cell adhesion to the extracellular matrix. It is now emerging as a promising therapeutic target in many tumour types due to its overexpression in tumour cells and is associated …