The ditopic ligand, L1, contains both a bipyridine domain and a tetra-azacrown binding domain. Introduction of one equivalent of Cu2+ ions results in co-ordination of the ion by all four of the available N-donor atoms in the azacrown unit. However, introduction of further Cu2+ i…
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Tropane alkaloids, containing the 8-azabicyclo[3.2.1]octane ring system, are widespread in Nature. This thesis describes the total synthesis of the tropane alkaloid ferrugine, isolated from the arboreal species Darlingiana ferruginea and attempted synthesis of ferruginine, isola…
The thesis is focussing on the interaction of lithium niobate with UV and ultrafast laser radiation to achieve 1) ferroelectric domain inversion, 2) waveguide fabrication, and 3) surface microstructuring. Preferential ferroelectric domain inversion has been demonstrated by 'late…
The late Pliocene is marked by the end of an interval of warm, relatively stable global climate and a secular shift into a bipolar glaciated world. The intensification of northern hemisphere glaciation (iNHG) central to this climatic transition was accompanied by a decrease in a…
This dissertation introduces the habitat use and spatial-temporal distribution of Cuvier’s beaked whale (Ziphius cavirostris, Cuvier, 1823) in the Bay of Biscay, from surveys carried out by the Biscay Dolphin Research Programme between 1995 and 2007. I have analysed the spatio-t…
This thesis explores the nature and ubiquity of iron (Fe) inputs from sediments to the oceans. In the last 10 years continental shelf sediments have become widely recognised as important vectors for dissolved Fe inputs to the oceans, where bacterial dissimilatory Fe-reduction (D…
The work described in this thesis focuses on two main topics: i) the study of the dynamic behaviour of metallo-supramolecular cylinders, that are known for their major groove DNA binding properties, and ii) the synthesis and DNA binding studies of the cylinders conjugated to sho…
A novel time-resolved velocity map ion imaging (TR-VMI) experiment has been constructed and successfully applied to the study of non-statistical dissociation processes. The photodissociation of NH3 following the population of the ν2 ’ = 4 umbrella vibrational mode of the first e…
The prodiginine antibiotics are produced by eubacteria, in particular members of the actinomycete family. Interest in this group of compounds has been stimulated by their antitumour, immunosuppressant and antimalarial activities at non-toxic levels. Streptomyces coelicolor A3(2)…
This thesis is concerned with the application of evanescent wave cavity ring-down spectroscopy (EW-CRDS) and evanescent wave broadband cavity enhanced absorption spectroscopy (EW-BB-CEAS) for studies of electrochemical and interfacial processes. These include nanoparticle adsorp…
This thesis is concerned with understanding and directing the functionalisation of solid surfaces with materials: molecules, nanoparticles and crystals. Both conducting (electrode) and insulating surfaces are of interest. For molecular functionalisation, a sweep potential proced…
Membrane proteins are involved in a wide range of vital cellular processes, responsible for relaying signals and cargo across cell membranes. A deeper molecular understanding of their function is essential to elucidate the mechanisms of numerous diseases and medical conditions. …
The development of several new gold-catalysed reactions are described. Two new strategies have been employed to access pyrroles by the cycloisomerisation of alkynyl aziridines, and the formation of α,β-unsaturated imides by the oxidation of ynamides has been developed. A rare go…
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a key enzyme in the conversion of cortisone to the functional glucocorticoid hormone cortisol. This activation has been implicated in several human disorders, notably the metabolic syndrome where 11β-HSD1 has been identified …
The work reported in this thesis is based around substitutions into bismuth oxide, which has proven to be highly adaptable chemically as it can accommodate a wide variety of substituents. The synthesis and characterisation of stabilised δ-Bi₂O₃ related materials containing small…
The reactions between antimony(v) chloride and the monocyclopentadienyl metal trichlorides of Group 4 (CpMCl3 for M = Ti, Sr and Hf) in acetonitrile solution have afforded new hexachloroantimonate salts. These cationic metal-containing products have been isolated and characteris…
This dissertation is divided into five chapters. Chapter One consists of an introduction to radical cyclisation and rearrangement reactions. Chapter Two investigates the reactions of substituted arylsulfonamides 278a-l with copper bromide and an amine ligand-TPA. This reaction i…
In this thesis the use of LFMM and the application of it to problems not typical tractable within a classical framework are detailed. The parameterisation of LFMM through the AOM is shown for a number of different metal ligand complexes. The developed parameters are then used to…