Mesenchymal stem cells (MSC) are a tissue-resident stromal cell population that are able to regulate immune responses, in particular the capacity for endothelial cells (EC) to support leukocyte recruitment. In this thesis we examined the ability of MSC from different sources (bo…
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Foetal growth and development is closely related to the placental transport function, since any defect in this function is associated with pathological foetal growth. Trophoblast differentiation into a multinucleate syncytium is a key biological mechanism. Transcriptional regula…
It is well documented that the perinatal period (the time from pregnancy until the first year of a child’s life) is a crucial window of opportunity for foetal and infant development. Evidence suggests that parental psychopathology can have harmful consequences for the parent-inf…
The Centre, a Charity founded by the Author in 1993, offers arts therapies interventions - Art, Dance Movement, Drama and Music - to clients of all ages and needs. This research represents an attempt to determine which modality of arts therapy should be recommended to any client…
Kidney Transplantation is the gold standard treatment for patients with end-stage renal failure. Most kidneys used for transplantation are from deceased donors and ensuring successful outcomes depends on many factors. One of these is organ storage. Hypothermic Machine Perfusion …
Donor organ shortage is a major barrier to the progress of liver transplantation; options to widen the donor pool include use of marginal donor grafts and those from donors after circulatory death (DCD), despite risks of early graft failure. This thesis studies the key metabolic…
The chronic fibrosing interstitial pneumonias (CFIPs) are diseases which cause progressive and often fatal progressive scarring of the lungs. The recent discovery of the first effective pharmacological therapies for this condition have increased interest in the monitoring of thi…
In order to understand the complex nature of the relationship between depression, anxiety and multiple sclerosis (MS) valid assessments are needed. The prevalence of anxiety and depression reported varies widely dependent on the assessment used, although it is often reported as …
Differing emphysema distribution in alpha-1-antitrypsin deficiency (A1AD) relates to specific lung function abnormalities. This thesis explores which factors need to be taken into account when defining A1AD phenotypes. Miller’s lung function prediction equations were the most ap…
Sepsis remains a common reason for hospital admission and is associated with a high mortality especially in the elderly. Neutrophils are one of the primary immune cells involved in the elimination of pathogens; however also contribute to the pathogenesis of multi-organ failure i…
Atherosclerosis is a chronic inflammatory disease, characterised by infiltration of leukocytes and accumulation of fatty deposits in the artery wall. Early events in this disease process include recruitment of platelets to the artery wall, which in turn aid in leukocyte recruitm…
The aim of this thesis is to examine the effect of anti-donor antibodies in the clinical management and outcomes of antibody incompatible kidney transplantation. Initial studies were conducted to improve measurement of anti-ABO specific blood group antibodies. The specificity of…
The mixed-lineage leukaemia 1 protein is a histone methyl-transferase that deposits the gene activating H3K4 trimethyl mark, and is often mutated in leukaemia. MLL1 is normally associated with a cohort of cofactors, but the mechanisms regulating the histone methyl-transferase ac…
I investigated the impact of DARC expression on haematopoiesis using DARC-deficient (DD) mice and developed humanised transgenic DARC models expressing the \(FYB(ES)\) and \(FYB\) human genes. I developed murine irradiation chimeras with differential DARC expression and showed t…
Multivariate meta-analysis methods combine e ect estimates for multiple correlated outcomes (such as systolic and diastolic blood pressure) from independent studies, utilising their between-study and within-study correlations. In contrast, a univariate meta-analysis pools effect…
Obesity is the single most important risk factor for the development of cardio-metabolic disease. As white adipose tissue dysfunction plays an essential role in inflammation and metabolic health, it would be beneficial to therefore investigate the influence of surgery, endocrine…
The obesity pandemic is one of the greatest challenges facing public health worldwide. With epidemiological projections forecasting only its acceleration, it is clear that the current anti-obesity approach has not been effective. This thesis seeks to outline, through a translatio…
This study postulates that there are currently four main dyslexia paradigms. These paradigms are: a) the Positivist-Intrinsic-Dyslexia-Paradigm, which reflects positivist studies on dyslexia that hold the etiological view that dyslexia exists intrinsically to the individual (of …
The interaction between the nervous and immune system is well documented, although is still not fully understood - particularly the impact of neurotransmitter receptors on immune cell function. 5-HT\(_3\)A receptor expression was identified on activated regulatory T cells (Treg)…