People faced with infertility will often experience a strong need for psychosocial support and guidance; a need which is not always adequately met by existing sources of support. The growth in access to the Internet over recent years has opened up new opportunities for people af…
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It is established that patients with knee osteoarthritis (OA) exhibit marked muscle weakness, one of the most frequent and earliest reported symptoms associated with knee OA. Weakness primarily affects the quadriceps muscle with little evidence of hamstring involvement. Traditio…
Resistance to β-lactam antibiotics in Campylobacter is often associated with the production of a β-lactamase; to date the genomically encoded bla\(_{OXA-61}\) and the closely related cj0299 are the only described β-lactamase genes of Campylobacter. Cj0299 of C. jejuni NCTC11168 …
The aim of this project was the study of neutrophil recruitment and reverse transmigration using murine and human in vitro models of inflammation. Murine in vitro models of inflammation were developed using an immortalised microvascular cell line (MCEC-1) and primary murine vasc…
Accelerated atherosclerosis and cardiovascular disease are seen in patients with primary vasculitis (PSV) and rheumatoid arthritis (RA). The mechanisms behind this remain unclear, but recent studies have linked it to endothelial cell dysfunction (ECD), which may result from the …
In order to advance our understanding of self-injury this longitudinal study investigated the experiences of 25 adults who had used or were using self-injury. This was achieved by obtaining verbal narrative accounts of their experiences of using self-injury from its onset during…
Astrocytes are the most abundant cell within the central nervous system (CNS) and yet despite this, the true extent of their role in health and disease has not been fully elucidated. In the undamaged CNS, they are termed quiescent, where they maintain homeostasis. However, after…
Low vitamin D is associated with an increased risk of autoimmune diseases, whose pathology might involve T\(_R\)\(_e\)\(_g\) and T\(_h\)17 dysregulation. Thus, understanding how vitamin D modifies CD4\(^+\) T-cell responses holds therapeutic potential. I therefore investigated t…
Diabetes is a chronic epidemic compounded by a burden of vascular complications including diabetic nephropathy. Diabetic nephropathy affects ~40% of patients and is characterised by increased urinary albumin excretion and decreased glomerular filtration rate. Diabetic patients e…
Troponin-I (TnI) is one of the three components that makes up the troponin complex, which along with tropomyosin regulates striated muscle contraction. The cardiac isoform of TnI (cTnI) has a ~30 residue N-terminal extension, which contains two serines (Ser22/23) that become pho…
Aims: To examine the metabolic changes associated with LVH secondary to AS, to examine the role of GIK as an adjunct to myocardial protection during AVR, and to examine the mechanism of its action. Methods: 220 patients with LVH secondary to AS were randomised 1:1 to receive an …
Recent studies have demonstrated a key role for platelets and microthrombi in the pathophysiology of intestinal ischaemia-reperfusion (IR) injury. The research described in this thesis investigates the role of the major platelet glycoprotein receptors in recruiting and activatin…
The relationship between antiretroviral treatment of HIV infection, body fat distribution, insulin resistance (HOMA), adipocytokine and apolipoprotein-B (apoB) kinetics was investigated in 12 HIV negative controls and 55 HIV-infected patients including antiretroviral treatment-n…
The cardiovascular system (CVS) has emerged as an important target of corticosteroid hormones. Mineralocorticoid receptor antagonists provide cardiovascular protection and are now routinely used in disorders such as primary hyperaldosteronism, resistant hypertension and congesti…
In a review of research on the relationship between shame and psychopathology it is suggested that too little attention has been paid to the actual context in which shame is experienced by people with psychological difficulties. An attempt is then made to link existing models of…
This thesis is based on a study of a consecutive series of acute head injured patients admitted to the Institute of Neurological Sciences in Glasgow over a three year period. Each patient had a CT scan performed which showed an acute traumatic intracranial haematoma. Literature …
Image segmentation of organs in medical images using model-based approaches requires a priori information which is often given by manually tagging landmarks on a training set of shapes. This is a tedious, time-consuming, and error prone task. To overcome some of these drawbacks,…
Over the last 20 years, an increasing number of research studies have shown that ultrasonography can provide a valid and accurate assessment of the median nerve and the pathological changes associated with median nerve disorders. More recently ultrasonographic technology has adv…
The secretory pathway Ca\(^{2+}\)-ATPase (SPCA) provides the Golgi apparatus with a luminal Ca\(^{2+}\) store, which is used to modulate the activity of Ca\(^{2+}\)-dependent enzymes involved in controlling the secretory pathway and post-translational modification of proteins. T…