Troponin-I (TnI) is one of the three components that makes up the troponin complex, which along with tropomyosin regulates striated muscle contraction. The cardiac isoform of TnI (cTnI) has a ~30 residue N-terminal extension, which contains two serines (Ser22/23) that become pho…
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Aims: To examine the metabolic changes associated with LVH secondary to AS, to examine the role of GIK as an adjunct to myocardial protection during AVR, and to examine the mechanism of its action. Methods: 220 patients with LVH secondary to AS were randomised 1:1 to receive an …
Recent studies have demonstrated a key role for platelets and microthrombi in the pathophysiology of intestinal ischaemia-reperfusion (IR) injury. The research described in this thesis investigates the role of the major platelet glycoprotein receptors in recruiting and activatin…
The relationship between antiretroviral treatment of HIV infection, body fat distribution, insulin resistance (HOMA), adipocytokine and apolipoprotein-B (apoB) kinetics was investigated in 12 HIV negative controls and 55 HIV-infected patients including antiretroviral treatment-n…
The cardiovascular system (CVS) has emerged as an important target of corticosteroid hormones. Mineralocorticoid receptor antagonists provide cardiovascular protection and are now routinely used in disorders such as primary hyperaldosteronism, resistant hypertension and congesti…
The aim of this study was to define new quantitative parameters of dynamic Pelvic Floor Muscle (PFM) function using 2D transperineal (TP) ultrasound imaging combined with image processing methods (IPM). Ultrasound and digital vaginal data were obtained from a volunteer convenien…
Essential hypertension is seen as a contemporary public health challenge not only because of its high prevalence and variable treatment response but also because it represents a major risk factor for cardiovascular disease. Both genetic and environmental factors contribute to th…
The role of the Clinical Psychologist has developed to incorporate that of the reflective practitioner. This thesis aims to consider how reflective practice is incorporated into personal and professional development by clinical psychologists and trainees, and what impact it may …
This research thesis has examined the way in which family involvement inchildhood Obsessive Compulsive Disorder (OCD) facilitates treatment andthe experiences of children in living with their diagnosis of OCD.Chapter one is a literature review of eleven empirical studies of thee…
This thesis consists of three papers, a literature review, an empirical paper and a reflective paper. The main focus of the literature review is on ‘understanding of minds’ and the development of this ability in siblings of children with a diagnosis on the autism spectrum (DAS).…
The aim of this study is to investigate the role of the internet within the area of mental health support. The first paper reviews the current literature surrounding the use of the internet for self-help and intervention purposes. It highlights investigations into the outcomes, …
The metabolic syndrome represents a state of insulin resistance, which has drawn great attention due to its public health importance. A quarter of the world’s adult population are considered to have the metabolic syndrome (Moadab et al. 2009). Despite having a striking phenotypi…
This thesis examined whether individuals with Autism Spectrum Disorders are sensitive to traits. The ability of individuals with Autism Spectrum Disorders to infer traits from descriptions of behaviour was investigated by asking participants to read trait implying sentences and …
As the incidence of type 2 diabetes rises exponentially in the early part of the 21st century, the global healthcare and financial burdens associated with this chronic condition rise in tandem. As such, it becomes increasingly important to characterise this disease further, and …
This thesis investigated the effect of acute psychological stress and \(β\)-adrenergic receptor (\(β\)AR) stimulation on the mobilization of CD8+ T lymphocytes (CD8TLs) and progenitor cell (PC) populations. Chapter 2 demonstrated that CD8TL stress- and \(β\)AR- sensitivity incre…
This thesis reports a clinical study designed to assess myocardial, renal and lung outcomes following cardiac surgery. In a single centre, prospective randomized, placebo intervention-controlled trial the effects of intermittent upper limb ischaemia (remote ischaemic preconditio…
Multivariate meta-analysis methods combine e ect estimates for multiple correlated outcomes (such as systolic and diastolic blood pressure) from independent studies, utilising their between-study and within-study correlations. In contrast, a univariate meta-analysis pools effect…
This thesis describes the development and evaluation of a self-monitoring and patient-initiated follow-up service for people with rheumatoid arthritis (RA) or psoriatic arthritis (PsA) on methotrexate. Using a mixed methods approach including a randomised controlled trial (RCT) …
Obesity is the single most important risk factor for the development of cardio-metabolic disease. As white adipose tissue dysfunction plays an essential role in inflammation and metabolic health, it would be beneficial to therefore investigate the influence of surgery, endocrine…