Thesiss

Little is known about the role of the gastrointestinal microbiota in susceptibility to infection with enteric pathogens and response to live oral vaccines. This study examined the effect of immunization with an oral live-attenuated Shigella dysenteriae 1 vaccine and challenge wi…

Shigella spp. are the etiologic agents of dysentery, a severe diarrheal syndrome characterized by acute inflammation in the colon. The inflammatory response, which includes recruitment of polymorphonuclear leukocytes (PMN), damages the colonic mucosa and exacerbates the infectio…

In clinical settings it is often important to know not just the identity of a microorganism, but also the danger posed by that particular strain. For instance, Escherichia coli can range from being a harmless commensal to being a very dangerous enterohemorrhagic (EHEC) strain. D…

Background: Shigella spp . and enteroinvasive Escherichia coli (EIEC) are prominent enteric pathogens and estimates of prevalence are limited by suboptimal sensitivity of current detection methods. Recent studies have suggested common co-infection and frequent asymptomatic patho…