It has been established in a number of research publications that a careful study of general handwriting features based on class characteristics could indicate either the place or the country where the writer was first taught to write. Using these studies as the basis, this rese…
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Currently, UK forensic service providers (FSPs) tend to employ three geographically-broad databases when estimating profile frequencies based on a standard SGM Plus® DNA profile. These estimations will typically include correction factors to take into account issues such as subs…
Ports are key members in the supply chain, therefore they are expected to provide reliable and efficient services. It has been recognised that one way to improve this is by adopting e-business solutions. Nowadays, a large number of organisations are operating their documents ele…
Nitric oxide (NO) generation by nitric oxide synthase (NOS) is implicated in gamete interaction and fertilization. In vitro studies were undertaken to assess the ability of human sperm and cumulus cells (surrounding the oocyte) to generate NO, investigate the mechanism of action…
Inflammation is widely considered to be an important contributing factor in atherogenesis and the risk of atherothrombotic complications. Baseline measurements of some inflammatory markers are known to be predictive risk factors for future cardiovascular disease (CVD) events in …
Background: This thesis examines the origins and early development of UK Biobank. This is a resource funded in 2002 by the Medical Research Council, the Wellcome Trust, the Department of Health and the Scottish Executive to gather genetic and lifestyle information from half a mi…
The tectonic development of the Western Indian high-elevation passive margin is complex. At least two major rifting events (India/Madagascar and India/Seychelles) and a major hotspot (The Reunion plume) are believed to have been instrumental in the formation and development of t…
The development of new drugs against Human African Trypanosomiasis is much needed due to toxicity, efficacy and availability problems with current drug treatments for this resurgent parasitic disease. Delivery of drugs into cells is an important determinant of therapeutic effica…
The traditional view of language comprehension is that the meaning of a sentence is composed of the meaning of each word combined into a fully specified syntactic structure. These processes are assumed to be generally completed fully and automatically. However, there is increasi…
The aim of this thesis was to structurally characterise a range of plant GSTs to increase the understanding as to which structural features determine substrate specificity. During the course of this work, a total of ten plant GSTs from species including Maize, Wheat, Carnation, …
Iron in coastal and sea water is readily complexed with organic matter (ligands) causing the formation of different species of iron, which affects its biogeochemistry. For this reason it is of interest to determine iron speciation in addition to its concentration. The chemical s…
Dairy calves in the U.K. are currently reared on ‘least cost’ principles, with minimal milk feeding and early weaning to solid foods. This has been described as maintaining the calf in ‘a state of chronic hunger’. As well as repercussions on calf health, growth and welfare, huma…
Due to the recent explosion of available data coming from the Web, sensor readings, social media, government authorities and scientific databases, both academia and industry have increased their interest in utilizing this knowledge. Processing huge amounts of data introduces sev…
Dental handpieces are used in a wide variety of dental treatment and oral surgery. During patient treatment handpieces becom contaminated with patient material. Due to the design and function of the dental handpieces, internal contamination of handpiece components frequently occ…
Chapter One contains the introduction, sets the context and aims of the research and highlights the original contribution to knowledge along with publications gained from this research. Chapter Two will cover the methodological choice, which is grounded theory, as well as highli…
Modern nuclear physics makes extensive use of exotic particle beams created using accelerators, such as unstable ion isotopes and antiprotons. These give access to a wide range of fundamental studies that are at the cutting edge of science. The commissioning and operation of the…
Resistance to pyrethroids, the only insecticide class approved for bednets, threatens the control of the major African malaria vectors, Anopheles funestus. In Malawi, where resistance has been previously reported, little is known about the nation-wide resistance profile, mechani…
Entamoeba histolytica is a parasitic protozoan that infects the human digestive tract. Infection results from ingestion of cyst-contaminated food or water. To date, E. histolytica infection remains a major worldwide public health problem in worldwide endemic areas. The spectrum …
Chronic lymphocytic leukaemia (CLL) is a lymphoid malignancy which despite advances in the treatment options available is still incurable. Characterised by the gradual accumulation of CD5+ B cells, the paradigm that this is due to failed apoptosis has been challenged and a signi…