This practice based research focuses on events of the body, using the participating observer-researcher's experiences of medical events undertaken by her within a western medical environment to investigate her living existence as a 'unit', an 'experiencing corporeal body'. The p…
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Thyroid hormones (THs) are important for fetoplacental development. Human intrauterine growth restriction (IUGR) is associated with malplacentation and reduced fetal circulating concentration of THs. The expression of the plasma membrane TH transporters MCT8, MCT10, LAT1, LAT2, …
Epithelial sodium channels (ENaC) are of immense importance, controlling Na+ transport across epithelia and thus playing a critical role in all aspects of fluid clearance as well as numerous other functions. Although extensive studies have been carried out to invistegate the reg…
Membrane proteins are involved in a wide range of vital cellular processes, responsible for relaying signals and cargo across cell membranes. A deeper molecular understanding of their function is essential to elucidate the mechanisms of numerous diseases and medical conditions. …
11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a key enzyme in the conversion of cortisone to the functional glucocorticoid hormone cortisol. This activation has been implicated in several human disorders, notably the metabolic syndrome where 11β-HSD1 has been identified …
The Xenopus pronephros is a simple paired organ; each nephron consists of a single large glomus, one set of tubules and a single duct. Previous work done in our laboratory demonstrates that the tubules and duct are specified at stages 12.5 and 14 respectively and the glomus is s…
Corticotrophin releasing hormone (CRH) and CRH receptor (CRH-R) appear to play a number of important roles in human pregnancy. The purpose of the first part of my project was to clone and sequence CRH-R subtypes from human myometrial biopsies. In order to understand the molecula…
Ribavirin, 1--D-ribofuranosyl-1,2,4-triazole-3-carboxamide, is a broad spectrum antiviral agent active against both DNA and RNA viruses. A range of 1,2,3-triazole, 1,2,4-triazole and benzotriazole analogues of ribavirin was synthesised using a crude extract of N-deoxyribosyltran…
It is well accepted that CHO ingestion can improve endurance performance. However, a number of questions remain open regarding fine-tuning CHO intake recommendations during prolonged endurance events. A way to measure the bioavailability of ingested CHO is to measure exogenous C…
Aims: To examine the interaction of maternal factors (body composition, physical activity, diet and cigarette consumption) with childhood factors (body composition, diet & physical activity) in the determination of bone mineral accrual by aged 6 years, assessed by a) bone densit…
Stair climbing is an ideal activity to promote in worksites due to its availability and associated health benefits. To date findings are equivocal regarding stair climbing intervention success in this setting, thus more research is needed. Chapter two of this thesis confirmed th…
Idiopathic intracranial hypertension (IIH) is a blinding condition amongst the young obese female population characterised by elevated intracranial pressure (ICP). The aetiology of IIH is not known and, as highlighted in the 2005 Cochrane review, an evidence base for treatment h…
Although most bacteria contain a single gene for the essential oligomeric chaperonin Cpn60, many contain two or more cpn60 genes. The non-pathogenic Mycobacterium smegmatis has three cpn60 homologues, while the pathogenic Mycobacterium tuberculosis has two. This study is a funct…
Pulmonary arterial hypertension (PAH) is a debilitating disease of small pulmonary resistance arteries with vasoconstriction and vascular remodelling contributing to the disease pathology. A genetic basis for the disease was linked to heterozygous loss of function mutations in t…
Gamma oscillations, synchronous network activity between 30 and 100 Hz, have been linked to higher cognitive functions. Adenosine receptor modulation has been shown to alter cognitive function in animals and humans. In this thesis the effects of adenosine receptor modulation on …
It has been suggested that a failure of angiogenesis (capillary growth) to keep pace with myocyte expansion is the driving force which pushes hypertrophied hearts into a state of failure marked by contractile dysfunction and alterations in the mechanisms governing energy product…
The adrenal steroid dehydroepiandrosterone (DHEA) and its sulphate ester, DHEAS are the most abundant circulating steroid hormones in humans. Uncongugated DHEA predominately exerts its effects via its downstream conversion to active sex steroids in peripheral target tissues. In …
This thesis describes approaches to further understand the structure and enzymology of D-Ala-D-Ala ligases (DDL) and those ligases with altered second substrate specificity, which confer glycopeptide antibiotic resistance. DDL is an essential enzyme in the biosynthetic pathway o…
Human aldo-keto reductases (AKR) of the 1C subfamily have been implicated in the progression of prostate, breast and endometrial carcinomas as well as leukaemias due to their ability to modify key signaling molecules: steroid hormones and prostaglandins (PGs). In leukaemia, the …