Actin polymerisation is a highly dynamic process which drives many cellular events, including endocytosis and cell motility. It is known that actin monomers are added to the filaments at the leading edge of a migrating cell and that this polymerisation is the driving force of pr…
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Ascending pathways in the spinal cord are very important in transmitting sensory information from the periphery to the higher brain centres. The spinothalamic tract represents an important component of these ascending pathways, and it has been traditionally described as the main…
Trypanosoma brucei evades host acquired immunity by antigenic variation, involving periodic switches in the variant surface glycoprotein (VSG) coat. DNA recombination is critical in this process and a key component of homologous recombination, RAD51, also plays a role in VSG swi…
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is a tissue–specific protein that promotes α4β7+ lymphocyte recruitment on gut mucosal endothelium, playing an important role in the development of inflammatory bowel disease (IBD). Recent studies have reported its expression…
Over the decades, the question why did neural organisation emerge in the way that it did? has proved to be massively elusive. Whilst much of the literature paints a picture of common ancestry the idea that a species at the root of the tree of nervous system evolution spawned num…
Nonsense mediated mRNA decay (NMD) is a translation-coupled process that preferentially destroys mRNAs harboring premature translation termination codons (PTCs). In mammalian cells, NMD is linked to pre-mRNA splicing. Typically, PTCs elicit strong NMD only if positioned upstream…
Analytical methods based on LC-ESI-MS/MS or LC-APPI-MS/MS were developed and/or validated for the separation and determination of BDE-209 and TBBP-A, in addition to HBCD diastereomers, enantiomers and degradation products in a wide range of samples including air, dust, diet, sim…
Individuals have limited time and energy and so they face a trade-off between the resources they allocate to parental, mating and self-maintenance activities and between care of current and future offspring. Within a biparental system, models predict that an individual will do b…
Conservation of phenotypically variable taxa such as the European whitefish (Coregonus lavaretus) can be particularly challenging. In this thesis it is argued that the recent designation of seven native C. lavaretus populations as three endemic species (C. clupeoides, C. stigmat…
Rotorcraft operating in ground effect have been known to experience beneficial performance effects as well as operational difficulties during low speed forward flight. While these have been attributed to the formation of the ground induced wake, limited experimental investigatio…
The relative contribution of different factors, including environmental and genetic variables, on the observed variation in genome numbers per oocyst was investigated. The variation in sporozoite numbers from two genetically different Plasmodium falciparum clones (3D7 and HB3) i…
This thesis mainly focuses on the adsorption behaviour of various molecules at the solid/liquid interface. The variation in adsorption kinetics are studied as a function of concentration, pH, applied electrode potential and surrounding environment by the surface sensitive analyt…
The physicochemical nature of the infectious agent in prion diseases creates a significant challenge for decontamination services. It has been shown to be both resistant to standard methods of decontamination, used to inactivate viruses and bacteria, and to associate avidly with…
A new evaluation has been made of the independent and cumulative yields of fission products for a selection of fissioning systems, including fission of nuclides important for reactor design and operation, and for fuel and waste management. The evaluation, which has been given th…
Protozoan parasites of the genus Leishmania are the causative agents of a complex of diseases referred to as leishmaniasis. Leishmania have a digenetic life cycle that involves a sand fly vector (promastigote stage) and a mammalian host (amastigote stage). The parasites reside w…
Olfactory ensheathing cells (OECs) are amongst the best candidates for cell transplantation into lesions of the central nervous system. These specialised glial cells are found in the olfactory system and are associated with the physiological restoration of neuronal circuitry in …
The prediction of protein-protein interactions (PPI) has recently emerged as an important problem in the fields of bioinformatics and systems biology, due to the fact that most essential cellular processes are mediated by these kinds of interactions. In this thesis we focussed i…
Autoimmune inflammatory reactions occur in a number of disorders to a variety of self antigens but the precise cellular and molecular mechanisms resulting in pathology are largely unresolved. In some instances T cell mediated reactions are thought to be the main contributors to …
Broadcasting is one of the fundamental data dissemination mechanisms in mobile ad hoc network (MANET), which is, for instance, extensively used in many routing protocols for route discovery process. The dynamic topology and limited communication bandwidth of such networks pose a…