This thesis represents a sociological exploration of Her Majesty’s Prison Service, male prisoners’ mental health, and the provision of National Health Service mental healthcare in a prison setting. This qualitative social science study is conducted in one prison establishment. T…
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This study is primarily concerned with the possible use and effectiveness of stress inoculation as a psychological preparation for combat. Initial fieldwork, in the form of a review of current practices and their supporting rationales, was carried out in military establishments …
A substantial proportion of people with dementia is cared for within long-term care settings. There is currently a greater recognition of the importance of providing for these individuals’ psychosocial needs, and “person-centred care” has emerged as an important approach. Dement…
This thesis aims to develop a new theoretical framework by which to understand family organisation and the processes of family therapy from a political perspective - a framework that will highlight (changing) power relationships rather than assume some notion of functional order…
This thesis has been concerned with how everyday social interactions facilitate personal change in the lives of therapeutic community (TC) client members. TCs are planned social environments that aim to provide a safe setting whereby troubling relational patterns can be explored…
The main focus of this thesis has been an investigation into the lives of men who have experienced some form of mental health problem. It has been suggested that mental illness may not be the most helpful way of conceptualising these experiences, as it presupposes the validity o…
A major challenge of the 21st century for the health-care professionals is to provide care for the ever-expanding population of people with renal-failure. Patient numbers are rising and specialist nurses, who are the pivotal factor in haemodialysis units, are becoming increasing…
This research to develop and validate the BILAG-2004 index for the assessment of disease activity in patients with [systemic lupus erythematosus] SLE had involved several validation studies. The reliability of this index was shown in 2 exercises, as assessed by level of agreemen…
Invariant natural killer T (iNKT) cells constitute an important regulatory arm of the immune system. Defects in the number and activities of iNKT cells have been linked to the development of autoimmune diseases. The glycoprotein CD1d plays an integral part in the recognition and…
Alpha-1-Antitrypsin Deficiency (AATD) is a risk factor for the development of early-onset emphysema and airflow obstruction. The current work defines exacerbations, lung function and health status in these patients including sibling pairs. Exacerbations occur commonly in AATD an…
Patients with diabetic renal disease develop elevated urinary albumin excretion rates [AER] and hypertension. Preliminary data from several groups suggest that diabetic patients handle transferrin, a protein similar in size and weight, in a different fashion from albumin. In the…
Regulated adherence of monocytes to extracellular matrix macromolecules is a prerequisite for their accumulation at sites of pulmonary infection and inflammation. To begin to assess the pathobiological importance of alterations in monocyte adherence to extracellular matrix in in…
Type 1 (insulin-dependent) diabetes mellitus is caused by autoimmune destruction of insulin-producing pancreatic ß-cells. Genetic susceptibility is necessary for the development of type 1 diabetes but inheritance does not follow simple Mendelian rules and environmental factors a…
Experimental meningitis was induced in pigmented guinea pigs by subarachnoid inoculation of \(1 \times 10^9\) Escherichia coli K-12 or \(3 \times 10^7\) CFU Streptococcus pneumoniae serotype 2 D39 (NCTC 7466) or PLN-A, \(Δ\)NA1 or \(Δ\)HY1, defined isogenic derivatives of D39 de…
A wider understanding of the impact of each of the dietary components on blood phenylalanine concentrations in PKU may lead to improvements in management. Knowledge of the effects of such rigorous diet therapy on feeding behaviour is also important. In a series of studies, the e…
This thesis is concerned with the realisation of leg cycling by means of FES in SCI individuals with complete paraplegia. FES lower-limb cycling can be safely performed by paraplegics on static ergometers or recumbent tricycles. In this work, different FES cycling systems were d…
The role of hydration in causing or alleviating suffering in patients with advanced cancer is poorly understood and remains controversial. Most dying cancer patients have reduced oral intake in the last days of life. This may be related to symptoms arising from the cancer or its…
Traumatic injury to the spinal cord interrupts ascending and descending pathways leading to severe functional deficits of sensory motor and autonomic function which depend on the level and severity of the injury. There are currently no effective therapies for treating such injur…