The accurate replication of the mammalian genome is a complex and logistically challenging process. The entirety of the genome must undergo a single duplication with as little error as possible. This must occur in a coordinated fashion and over suitably short time scale so as to…
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Change from a regulated to deregulated structure means that, the centralized maintenance system is not valid any more. In the surveyed published literature, there is not a single model which incorporates all maintenance cost components to analyze the effect of different maintena…
Scheduling large real world problems is a complex process and finding high quality solutions is not a trivial task. In cooperation with Trimble MRM Ltd., who provide scheduling solutions for many large companies, a problem is identified and modelled. It is a general model which …
Chemical kinetics has been widely acknowledged as a fundamental theory in analysis of chemical processes and the corresponding reaction outputs and rates. The study and application of chemical kinetics thus provide a simulation tool to predict many characteristics a chemical pro…
Dynamic modelling and optimization of three different processes namely (a) bulk polymerization of styrene, (b) solution polymerization of methyl methacrylate (MMA) and (c) emulsion copolymerization of Styrene and MMA in batch and semi-batch reactors are the focus of this work. I…
This thesis is concerned with developing and implementing a method for modelling and projecting cancer incidence data. The burden of cancer is an increasing problem for society and therefore, the ability to analyse and predict trends in large scale populations is vital. These pr…
This research is concerned with improving the planning process in large construction projects where the management and planning of the preconstruction planning process itself is a significant and complex task. Preconstruction planning in the construction sector has become a comp…
This thesis focuses on the incorporation of carbon nanoparticles within continuous fibre reinforcements by liquid composite moulding processes, in order to provide enhanced electrical and delamination properties to the multiscale composites. The mechanisms controlling the flow a…
This thesis presents both a study of the cluster-scale environments in which massive stars form, investigating in particular how the ionized gas in these regions relates to the molecular star-forming material, as well as detailed studies of two luminous forming stars, AFGL 2591 …
In 1996, a concept was proposed by the UK Ministry of Defence with the intention of making the field of reliability more useful to the end user, particularly within the field of military aerospace. This idea was the Maintenance Free Operating Period (MFOP), a duration of time in…
The safety and functionality of engineering systems can be affected adversely by faults or wear in system components. Therefore, methods for detecting such faults/wear and ameliorating their effects to avoid system failure are important. Designing schemes for the detection and d…
Incidental catch, or bycatch, of harbour porpoise (Phocoena phocoena) in fishing operations is an international conservation issue. The main objective of this thesis was to develop methods for determining the impact of bycatch on the state and dynamics of porpoise populations an…
In the last few decades, the emergence of large-scale infrared surveys has led to a revolution in the study of star formation. In particular, NASA’s Spitzer Space Telescope has recently carried out mid- and far-infrared observations of numerous star formation regions with unprec…
Desalination technology provides fresh water to the arid regions around the world. Multi-Stage Flash (MSF) distillation process has been used for many years and is now the largest sector in the desalination industry. Top Brine Temperature (TBT) (boiling point temperature of the …
Biotechnology is witnessing a remarkable growth evident both in the types of new products and in the innovative new processes developed. More efficient process design, optimisation and troubleshooting can be achieved through a better understanding of the underlying biological pr…
While premature birth is still one of the major clinical problems worldwide, the exact physiological mechanisms underlying myometrium activity during pregnancy remain unclear. In this thesis, a novel biophysically detailed model was constructed using available experimental data …
The growing number of micro generation devices in the electrical network is leading many to consider that these devices can no longer be considered as fit and forget, but should instead be considered as having a demonstrable network impact which should be predicted and utilised.…
This thesis describes the metallurgical and environmental factors that influence hydrogen embrittlement of super duplex stainless steels and presents a model to predict the rate at which embrittlement occurs. Super duplex stainless steel has an austenite and ferrite microstructu…
Monthly unimpaired flow calculations have been at the heart of hydrologic forecasting and water management in California for decades. Yet only recently have daily unimpaired flow calculations been applied directly to state-level water management policy. In 2018, the California S…